Why digital development tools?
Developing solid oral dosage forms and advanced drug delivery systems is complex and resource-intensive.
Every formulation step, from powder blending to compaction, coating, and dissolution, involves multiple, interdependent material and process parameters.
Small variations in particle size, morphology, porosity, or compaction can affect flow, mechanical stability, hardness, and dissolution profile.
Traditional trial-and-error methods require many prototypes, consuming time and resources.
Challenges and their solution with GeoDict:
- Powder characterization: Understand how particle size, shape, and surface properties influence flow, density, and blend homogeneity
- Mixing: Predict compaction behavior and density gradients in tablets or beads.
- Tablet microstructure: Assess mechanical robustness, friability, and crack initiation
- Dissolution and release: Adjust release kinetics by tuning porosity, tortuosity, and coating thickness.
- QbD: Run large parameter studies to identify critical parameters in sensitivity studies.
- Regulatory alignment: Provide transparent, physics-based workflows with full traceability for MIDD strategies.
Digitalization & Image Processing
- Segment and convert μCT scans into 3D digital structures
of powders, tablets, pellets, capsules ... with image filters and
Al tools. - These digital structures are the basis for analysis and
multiphysics simulations.
Non-destructive Analysis & Quality Control
- Extract grain & pore size distribution, packing density, porosity, tortuosity, and coating thickness directly from 3D scans.
- Perform digital testing of stability and dissolution without
destroying samples. - Enable simulation-based analytics for reliable quality control.
Digital Twins & Digital Siblings
- Build digital twins of powders, granules, tables, capsules,
and more in full 3D detail from parameters extracted from
digital analysis. - Generate digital siblings by systematically varying particle
morphology, excipient ratios, compaction force, or coatings
uniformity. - Conduct sensitivity analysis and virtual scale-up prior
to manufacturing.
Property Prediction
- Run multiphysics simulations to predict packing, compaction, mechanical robustness, friability, permeability, release, and dissolution kinetics.
- Directly link microstructure to critical quality attributes.
- Support QbD strategies, regulatory submissions, and high reproducible, accelerated formulation development with physic-based predictions.
The GeoDict solution for the digitalization of pharmaceutical formulation
In addition to GeoDict Base, the GeoDict package includes all necessary modules for the research and development of pharmaceutical formulation.
Module recommendations
| Image Processing & Image Analysis | ImportGeo-Vol | ||
| Characterization & Analysis | PoroDict + MatDict | GrainFind-AI | |
| Modeling & Design | GrainGeo | ||
| Simulation & Prediction | FlowDict | DiffuDict | ElastoDict |
Which modules are the best fit for you depends on the nature of your application.
